
Psilocybin Outside the Clinic: Public Health Challenges of Increasing Publicity, Accessibility, and Use
Published in JAMA Psychiatry, 2025
This review synthesizes emerging data on psilocybin use trends, product variability, co-use with other substances, and adverse event reports. It highlights parallels with the cannabis legalization trajectory, showing that potency, product diversity, and unsupervised use are increasing while regulation and public education lag behind.
Recommended citation: Hutchison KE, Hooper JF, Karoly, HC. (2025). Psilocybin Outside the Clinic: Public Health Challenges of Increasing Publicity, Accessibility, and Use. JAMA Psychiatry. 2025 Nov 5. doi: 10.1001/jamapsychiatry.2025.3038.
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